Biological response to ß-tricalcium phosphate/calcium sulfate synthetic graft material: an experimental study.
Implant Dent
; 23(1): 37-43, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24384743
ABSTRACT
PURPOSE:
The aim of this study was to evaluate the effect of a biphasic synthetic bone graft material composed of ß-tricalcium phosphate (ß-TCP) and calcium sulfate (CS) in 12 New Zealand rabbits. MATERIALS ANDMETHODS:
A circular bicortical critical-size cranial defect was created in each of 12 rabbits. The defects were grafted with ß-TCP/CS. Animals were euthanized at 3 and 6 weeks. Harvested tissue specimens were evaluated histologically and histomorphometrically. Parameters associated with new bone formation and graft resorption were measured and calculated. The results were statistically analyzed using the Mann-Whitney test.RESULTS:
Our data demonstrated the biocompatibility of synthetic ß-TCP/CS, as no inflammatory response was observed, and no fibrosis was developed between the graft particles and the newly formed bone. Moreover, ß-TCP/CS acted as an osteoconductive scaffold that allowed a significant bone regeneration and graft biodegradation with time.CONCLUSION:
In this animal model, synthetic ß-TCP/CS proved to be a biocompatible, osteoconductive, and bioresorbable bone graft substitute.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração Óssea
/
Fosfatos de Cálcio
/
Sulfato de Cálcio
/
Transplante Ósseo
/
Substitutos Ósseos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article