TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.

Ferguson, Annabel A; Roy, Sudipa; Kormanik, Kaitlyn N; Kim, Yongsoon; Dumas, Kathleen J; Ritov, Vladimir B; Matern, Dietrich; Hu, Patrick J; Fisher, Alfred L

Ferguson, Annabel A; Roy, Sudipa; Kormanik, Kaitlyn N; Kim, Yongsoon; Dumas, Kathleen J; Ritov, Vladimir B; Matern, Dietrich; Hu, Patrick J; Fisher, Alfred L.

Afiliação

Ferguson AA; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Roy S; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America ; Center for Healthy Aging, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
Kormanik KN; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Kim Y; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.
Dumas KJ; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America.
Ritov VB; Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Matern D; Biochemical Genetics Laboratory, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.
Hu PJ; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America ; Departments of Internal Medicine and Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Fisher AL; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America ; Center for Healthy Aging, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America ; GRECC, South Texas VA Health Care System

PLoS Genet ; 9(12): e1004020, 2013.

Article em En | MEDLINE | ID: mdl-24385923

Assuntos

Proteínas de Caenorhabditis elegans/genética; Caenorhabditis elegans/crescimento & desenvolvimento; Longevidade/genética; Redes e Vias Metabólicas/genética; Tirosina Transaminase/genética; Tirosina/genética; Animais; Animais Geneticamente Modificados; Caenorhabditis elegans/genética; Fatores de Transcrição Forkhead; Regulação da Expressão Gênica no Desenvolvimento; Proteínas de Fluorescência Verde; Humanos; Insulina/metabolismo; Fator de Crescimento Insulin-Like I/metabolismo; Larva/genética; Larva/crescimento & desenvolvimento; Larva/metabolismo; Mutação; Interferência de RNA; Receptor de Insulina/metabolismo; Fatores de Transcrição/genética; Tirosina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina / Tirosina Transaminase / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Redes e Vias Metabólicas / Longevidade Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2013 Tipo de documento: Article

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