Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo.
Virus Res
; 181: 22-6, 2014 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-24389095
ABSTRACT
Influenza is a major burden to public health. Due to high mutation rates and selection pressure, mutant viruses emerge which are resistant to currently used antiviral drugs. Therefore, there is a need for the development of novel classes of antiviral drugs that suffer less from the emergence of resistant viruses. Antiviral drugs based on collectin-like surfactant protein D (SP-D) may fulfil these requirements. Especially porcine SP-D displays strong antiviral activity to influenza A viruses. In the present study the antiviral activity of recombinant porcine SP-D was investigated in ex vivo cultures of respiratory tract tissue infected with human influenza A virus of the H3N2 subtype. Porcine SP-D has antiviral activity in these test systems. It is suggested that porcine SP-D may be used as a venue to develop a novel class of antiviral drugs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza A
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Replicação Viral
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Proteínas Recombinantes
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Proteína D Associada a Surfactante Pulmonar
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article