Expedient synthesis of α-heteroaryl piperidines using a Pd-catalyzed Suzuki cross-coupling-reduction sequence.
Org Lett
; 16(2): 413-5, 2014 Jan 17.
Article
em En
| MEDLINE
| ID: mdl-24392999
ABSTRACT
A method for the modular synthesis of α-heteroaryl piperidines is reported. The two-step procedure consists of an initial Pd-catalyzed Suzuki cross-coupling of the heteroaryl bromide with a boronate ester derived from N-Boc piperidone, followed by subsequent tetrahydropyridine reduction. Using this method, α-heteroaryl piperidine products featuring a broad range of pharmaceutically relevant azine and diazine substitutions have been prepared.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Paládio
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Piperidinas
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Compostos Heterocíclicos
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Hidrocarbonetos Bromados
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article