Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain.

Meng, Yu; Sohar, Istvan; Sleat, David E; Richardson, Jason R; Reuhl, Kenneth R; Jenkins, Robert B; Sarkar, Gobinda; Lobel, Peter

Meng, Yu; Sohar, Istvan; Sleat, David E; Richardson, Jason R; Reuhl, Kenneth R; Jenkins, Robert B; Sarkar, Gobinda; Lobel, Peter.

Afiliação

Meng Y; Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA.
Sohar I; Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA.
Sleat DE; Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Richardson JR; Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
Reuhl KR; Department of Pharmacology & Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, USA.
Jenkins RB; Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Sarkar G; Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, USA; Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, USA.
Lobel P; Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey, USA; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA. Electronic address: lobel@cabm.rutgers.edu.

Mol Ther ; 22(3): 547-553, 2014 Mar.

Article em En | MEDLINE | ID: mdl-24394185

Assuntos

Aminopeptidases/metabolismo; Apolipoproteínas E/metabolismo; Barreira Hematoencefálica/metabolismo; Dipeptidil Peptidases e Tripeptidil Peptidases/metabolismo; Lipofuscinoses Ceroides Neuronais/tratamento farmacológico; Lipofuscinoses Ceroides Neuronais/fisiopatologia; Peptídeos/administração & dosagem; Serina Proteases/metabolismo; Administração Intravenosa; Animais; Células CHO; Cricetulus; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Terapia de Reposição de Enzimas; Humanos; Lisossomos/metabolismo; Camundongos; Lipofuscinoses Ceroides Neuronais/patologia; Proteínas Recombinantes; Tripeptidil-Peptidase 1

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Peptídeos / Barreira Hematoencefálica / Dipeptidil Peptidases e Tripeptidil Peptidases / Serina Proteases / Aminopeptidases / Lipofuscinoses Ceroides Neuronais Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google