p53-Dependent suppression of genome instability in germ cells.

Otozai, Shinji; Ishikawa-Fujiwara, Tomoko; Oda, Shoji; Kamei, Yasuhiro; Ryo, Haruko; Sato, Ayuko; Nomura, Taisei; Mitani, Hiroshi; Tsujimura, Tohru; Inohara, Hidenori; Todo, Takeshi

Otozai, Shinji; Ishikawa-Fujiwara, Tomoko; Oda, Shoji; Kamei, Yasuhiro; Ryo, Haruko; Sato, Ayuko; Nomura, Taisei; Mitani, Hiroshi; Tsujimura, Tohru; Inohara, Hidenori; Todo, Takeshi.

Afiliação

Otozai S; Department of Otorhinolaryngology and Head and Neck Surgery, Osaka University School of Medicine, Osaka 565-0871, Japan.
Ishikawa-Fujiwara T; Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, B4, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Oda S; Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan.
Kamei Y; Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, B4, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Ryo H; Nomura Project, National Institute of Biomedical Innovation, Osaka 565-0085, Japan.
Sato A; Department of Pathology, Hyogo College of Medicine, Hyogo 663-8501, Japan.
Nomura T; Nomura Project, National Institute of Biomedical Innovation, Osaka 565-0085, Japan.
Mitani H; Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan.
Tsujimura T; Department of Pathology, Hyogo College of Medicine, Hyogo 663-8501, Japan.
Inohara H; Department of Otorhinolaryngology and Head and Neck Surgery, Osaka University School of Medicine, Osaka 565-0871, Japan.
Todo T; Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, B4, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: todo@radbio.med.osaka-u.ac.jp.

Mutat Res ; 760: 24-32, 2014 Feb.

Article em En | MEDLINE | ID: mdl-24406868

Assuntos

Peixes/genética; Instabilidade Genômica/genética; Células Germinativas/patologia; Proteína 2 Homóloga a MutS/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Sequência de Aminoácidos; Animais; Raios gama/efeitos adversos; Instabilidade Genômica/efeitos da radiação; Células Germinativas/metabolismo; Células Germinativas/efeitos da radiação; Masculino; Dados de Sequência Molecular; Proteína 2 Homóloga a MutS/genética; Homologia de Sequência de Aminoácidos; Proteína Supressora de Tumor p53/genética

Palavras-chave

CE; DDR; DNA damage response; DSB; ESTR; HRM; MMR; MSI; Medaka fish; Microsatellite instability; Radiation; Spermatogonial stem cell; TILLING; double-strand break; expanded simple tandem repeat; fluorescent capillary electrophoresis; high-resolution melting; microsatellite instability; mismatch-repair; msh2; p53; target induced local lesion in genome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Instabilidade Genômica / Proteína 2 Homóloga a MutS / Peixes / Células Germinativas Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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