Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.

Dowling, Jennifer K; Becker, Christine E; Bourke, Nollaig M; Corr, Sinead C; Connolly, Dympna J; Quinn, Susan R; Pandolfi, Paolo P; Mansell, Ashley; O'Neill, Luke A J

Dowling, Jennifer K; Becker, Christine E; Bourke, Nollaig M; Corr, Sinead C; Connolly, Dympna J; Quinn, Susan R; Pandolfi, Paolo P; Mansell, Ashley; O'Neill, Luke A J.

Afiliação

Dowling JK; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Becker CE; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Bourke NM; Centre for Innate Immunity and Infectious Disease, MIMR-PHI Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.
Corr SC; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Connolly DJ; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Quinn SR; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Pandolfi PP; Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 01605.
Mansell A; Centre for Innate Immunity and Infectious Disease, MIMR-PHI Institute of Medical Research, Monash University, Clayton, Victoria 3168, Australia.
O'Neill LAJ; Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, Trinity College Dublin, Pearse Street, Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.

J Biol Chem ; 289(10): 6429-6437, 2014 Mar 07.

Article em En | MEDLINE | ID: mdl-24407287

Assuntos

Proteínas do Citoesqueleto/metabolismo; Inflamassomos/metabolismo; Proteínas Nucleares/metabolismo; Fatores de Transcrição/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Proteínas Adaptadoras de Sinalização CARD; Proteínas de Transporte/metabolismo; Linhagem Celular Tumoral; Núcleo Celular/metabolismo; Proteínas do Citoesqueleto/genética; Citosol/metabolismo; Proteínas de Ligação a DNA; Células HEK293; Humanos; Macrófagos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR; Proteínas Nucleares/genética; Proteína da Leucemia Promielocítica; Multimerização Proteica; Fatores de Transcrição/genética; Proteínas Supressoras de Tumor/genética

Palavras-chave

Cancer; Cytokine; Inflammasome; Inflammation; Innate Immunity; Nod-like Receptors (NLR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Proteínas do Citoesqueleto / Proteínas Supressoras de Tumor / Inflamassomos Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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