Environment-dependent conformation and antimicrobial activity of a gramicidin S analog containing leucine and lysine residues.
FEBS Lett
; 220(2): 332-6, 1987 Aug 17.
Article
em En
| MEDLINE
| ID: mdl-2440729
ABSTRACT
An analog of gramicidin S, cyclo(-L-Leu-L-Lys-L-Leu-D-Leu-L-Leu-)2, in which four out of five amino acid components of gramicidin S were substituted, has been synthesized. This analog assumes a conformation similar to that of gramicidin S in acidic liposomes and a random conformation in neutral liposomes. The antimicrobial activity of this analog corresponded to one-fourth of that of gramicidin S. A possible mechanism for conformational changes in acidic liposomes is discussed.
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Base de dados:
MEDLINE
Assunto principal:
Gramicidina
/
Antibacterianos
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article