Pten regulates zebrafish hematopoiesis.
Blood
; 123(2): 149-50, 2014 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-24408201
ABSTRACT
In this issue of Blood, Choorapoikayil et al have used phosphatase and tensin homolog (Pten)deficient zebrafish to uncover prominent roles for Pten loss in enhancing proliferation of hematopoietic stem cells (HSCs) and eliciting differentiation arrest within lineage-committed blood progenitor cells. These results provide novel insights into the early genetic events that predispose blood cells to malignant transformation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Diferenciação Celular
/
PTEN Fosfo-Hidrolase
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article