Synthesis of pyridyl-dihydrobenzooxaphosphole ligands and their application in asymmetric hydrogenation of unfunctionalized alkenes.
J Org Chem
; 79(3): 993-1000, 2014 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-24410322
ABSTRACT
Synthesis of the electron-rich 2-substituted-6-(phenylsulfonyl)pyridines is presented. A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed and synthesized by a diastereoselective S(N)Ar substitution of the corresponding sulfonyl pyridines. The ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of unfunctionalized alkenes with good enantioselectivities.
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Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Compostos de Fósforo
/
Irídio
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article