CD8(+) T cells producing IL-3 and IL-5 in non-IgE-mediated eosinophilic diseases.
Allergy
; 68(12): 1622-5, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24410785
ABSTRACT
The cytokines IL-5, IL-3, and GM-CSF are crucial for eosinophil development, survival, and function. To better understand their role in non-IgE-mediated eosinophilic diseases, we investigated plasma levels of these cytokines as well as cytokine expression in peripheral blood T cells. While we did not find any evidence for an involvement of T-cell-derived GM-CSF, some of these patients did show an increased proportion of IL-5- or IL-3-producing CD4(+) T cells. However, in a significant proportion of patients, IL-5-producing CD8(+) T cells, so-called Tc2 cells, which in healthy donors can only be detected at very low levels, were prominent. Furthermore, increased IL-3 production by CD8(+) T cells was also observed, strongly supporting the notion that CD8(+) T cells, not just CD4(+) T cells, must also be considered as a potential source of the cytokines promoting eosinophilia.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-5
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Interleucina-3
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Linfócitos T CD8-Positivos
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Eosinofilia
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article