RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions.
Neurosci Biobehav Rev
; 46 Pt 2: 302-14, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24412241
ABSTRACT
A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cognição
/
Proteínas rab de Ligação ao GTP
/
Moduladores de Transporte de Membrana
/
Proteínas do Tecido Nervoso
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article