Your browser doesn't support javascript.
loading
A greener, efficient approach to Michael addition of barbituric acid to nitroalkene in aqueous diethylamine medium.
Al-Najjar, Hany J; Barakat, Assem; Al-Majid, Abdullah M; Mabkhot, Yahia N; Weber, Manuel; Ghabbour, Hazem A; Fun, Hoong-Kun.
Afiliação
  • Al-Najjar HJ; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. hany_33@hotmail.com.
  • Barakat A; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. ambarakat@ksu.edu.sa.
  • Al-Majid AM; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. amajid@ksu.edu.sa.
  • Mabkhot YN; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. yahia@ksu.edu.sa.
  • Weber M; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. manuelweber@berkeley.edu.
  • Ghabbour HA; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. ghabbourh@yahoo.com.
  • Fun HK; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. hfun.c@ksu.edu.sa.
Molecules ; 19(1): 1150-62, 2014 Jan 17.
Article em En | MEDLINE | ID: mdl-24445342
An efficient method for the synthesis of a variety of pyrimidine derivatives 3a-t by reaction of barbituric acids 1a,b as Michael donor with nitroalkenes 2a-k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by 1H-NMR, 13C-NMR, CHN, IR, and MS. The structure of compound 3a was further confirmed by single crystal X-ray structure determination.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barbitúricos / Dietilaminas / Nitrocompostos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barbitúricos / Dietilaminas / Nitrocompostos Idioma: En Ano de publicação: 2014 Tipo de documento: Article