Quantification of sweat gland volume and innervation in neuropathy: Correlation with thermoregulatory sweat testing.
Muscle Nerve
; 50(4): 528-34, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24449525
ABSTRACT
INTRODUCTION:
No study has correlated thermoregulatory sweat testing (TST) with histopathologic study of sweat glands (SGs) and SG nerve fibers (SGNFs).METHODS:
We studied 10 neuropathy patients in whom anhidrosis was found by TST and 10 matched controls. Skin biopsies were taken from both anhidrotic and sweating skin and immunohistochemical staining was done for nerves and basement membrane. For each biopsy, total tissue volume, total SG volume, and total SGNF length were measured. SGNF length per biopsy volume, SG volume per biopsy volume (SG%), and SGNF length per SG volume were calculated.RESULTS:
SGNF length per biopsy volume was reduced in anhidrotic site biopsies of patients compared with controls. SG% was decreased and SGNF length per SG volume increased in patients compared with controls.CONCLUSIONS:
The results suggest a concomitant loss of SG volume and SGNF length in neuropathy, with greater loss of SGNFs in anhidrotic skin, possibly exceeding collateral reinnervation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Suor
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Glândulas Sudoríparas
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Regulação da Temperatura Corporal
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Doenças do Sistema Nervoso Periférico
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article