[Research of grape seed powder on serum lipids and hepatic protection effects in high-fat diet rats].

ABSTRACT

OBJECTIVE: To research of grape seed powder on serum lipids and hepatic protection effects in high-fat diet rats. METHODS: The rats were divided into five groups, every group wastaken high-fat diet except control group, the physiological saline was administered to the control group and the high-fat diet groups. The doses of grape seed power in low, middle and high groups were determined based on the 1x , 5x , and 10x standard human doses (20 mg/60 kg BW), respectively. The rats were orally given test sample respectively for 28 days, once a day. Observed the changes of erum lipids and live pathology. RESULTS: Compared to the control group, the serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were increased significantly (P < 0.05) and HDL-C markedly decreased (P < 0.05) in high-fat diet group. The histological data with light microscopy demonstrated that the fatty degeneration in liver was significantly attenuated in grape seed powder rats as compared to high-fat diet group. CONCLUSION: The grape seed powder can reduce the level of serum lipids and prevent the occurrence of fatty liver.