Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/reperfusion through downregulation of aquaporin 4 expression.

Zhou, Yun; Li, Hui-qin; Lu, Lin; Fu, Deng-lei; Liu, Ai-ju; Li, Ji-huang; Zheng, Guo-qing

Zhou, Yun; Li, Hui-qin; Lu, Lin; Fu, Deng-lei; Liu, Ai-ju; Li, Ji-huang; Zheng, Guo-qing.

Afiliação

Zhou Y; The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Li HQ; The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Lu L; The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Fu DL; The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Liu AJ; The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Li JH; The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Zheng GQ; The Center of Neurology and Rehabilitation, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China. Electronic address: gq_zheng@sohu.com.

Phytomedicine ; 21(7): 998-1003, 2014 Jun 15.

Article em En | MEDLINE | ID: mdl-24462216

Assuntos

Barreira Hematoencefálica/efeitos dos fármacos; Isquemia Encefálica/tratamento farmacológico; Ginsenosídeos/farmacologia; Fármacos Neuroprotetores/farmacologia; Traumatismo por Reperfusão/prevenção & controle; Animais; Aquaporina 4/genética; Aquaporina 4/metabolismo; Modelos Animais de Doenças; Regulação para Baixo/efeitos dos fármacos; Regulação da Expressão Gênica/efeitos dos fármacos; Masculino; Ratos Sprague-Dawley; Traumatismo por Reperfusão/tratamento farmacológico

Palavras-chave

Aquaporin 4; Blood brain barrier disruption; Ginsenoside Rg1; Neuroprotection; Stroke

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Traumatismo por Reperfusão / Isquemia Encefálica / Fármacos Neuroprotetores / Ginsenosídeos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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