Lupane triterpenoids from the stems of Euonymus carnosus.
J Nat Prod
; 77(2): 276-84, 2014 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-24467317
ABSTRACT
Fifteen new lupane-type triterpenoids (1-15) and 10 known triterpenoids (16-25) were isolated from the stems of Euonymus carnosus. The structures of the new compounds were elucidated on the basis of spectroscopic analyses, and the absolute configuration of compound 1 was confirmed by X-ray crystallographic analysis using anomalous scattering of Cu Kα radiation. In addition, the compounds were tested for their cytotoxic activity against five human cancer cell lines and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line. Compound 11 exhibited moderate cytotoxicity against several human cancer cell lines, and compounds 1, 2, 4, 5, 20, and 25 showed neuritis inhibitory activity against microglial inflammation factor, with IC50 values of 7.39, 7.48, 7.80, 3.48, 2.54, and 6.09 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Medicamentos de Ervas Chinesas
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Euonymus
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Anti-Inflamatórios
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Antineoplásicos Fitogênicos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article