Heat shock-induced dissociation of TRF2 from telomeres does not initiate a telomere-dependent DNA damage response.
Cell Biol Int
; 38(5): 675-81, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24474557
ABSTRACT
Telomeric repeat binding factor 2 (TRF2) is a well-studied shelterin complex subunit that plays a major role in the protection of chomosome ends and the prevention of the telomere-associated DNA damage response. We show that heat shock induces the dissociation of TRF2 from telomeres in human primary and cancer cell cultures. TRF2 is not simply degraded in response to heat shock, but redistributed thoughout the nucleoplasm. This TRF2 depletion/redistribution does not initiate the DNA damage response at chomosome termini.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
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Telômero
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Proteína 2 de Ligação a Repetições Teloméricas
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Temperatura Alta
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article