Direct synthesis of 1,4-diols from alkenes by iron-catalyzed aerobic hydration and C-H hydroxylation.
Angew Chem Int Ed Engl
; 53(10): 2730-4, 2014 Mar 03.
Article
em En
| MEDLINE
| ID: mdl-24488606
ABSTRACT
Various 1,4-diols are easily accessible from alkenes through iron-catalyzed aerobic hydration. The reaction system consists of a user-friendly iron phthalocyanine complex, sodium borohydride, and molecular oxygen. Furthermore, the effect of additional ligands on the iron complex was examined for a model reaction. The second hydroxy group is installed by direct C(sp(3))-H oxygenation, which is based on a [1,5]â
hydrogen shift process of a transient alkoxy radical that is formed by formal hydration of the olefin.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Álcoois
/
Alcenos
/
Ferro
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article