Tritium labeling of detonation nanodiamonds.
Chem Commun (Camb)
; 50(22): 2916-8, 2014 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-24492594
ABSTRACT
For the first time, the radioactive labeling of detonation nanodiamonds was efficiently achieved using a tritium microwave plasma. According to our measurements, the total radioactivity reaches 9120 ± 120 µCi mg(-1), with 93% of (3)H atoms tightly bonded to the surface and up to 7% embedded into the diamond core. Such (3)H doping will ensure highly stable radiolabeled nanodiamonds, on which surface functionalization is still allowed. This breakthrough opens the way to biodistribution and pharmacokinetics studies of nanodiamonds, while this approach can be scalable to easily treat bulk quantities of nanodiamonds at low cost.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trítio
/
Nanodiamantes
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article