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Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.
Kumar, Nag S; Dullaghan, Edie M; Finlay, B Brett; Gong, Huansheng; Reiner, Neil E; Jon Paul Selvam, J; Thorson, Lisa M; Campbell, Sara; Vitko, Nicholas; Richardson, Anthony R; Zoraghi, Roya; Young, Robert N.
Afiliação
  • Kumar NS; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada.
  • Dullaghan EM; Centre for Drug Research and Development (CDRD), Vancouver, BC, Canada.
  • Finlay BB; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada.
  • Gong H; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada.
  • Reiner NE; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada; Department of Microbiology and Immunology, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
  • Jon Paul Selvam J; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada.
  • Thorson LM; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada.
  • Campbell S; Centre for Drug Research and Development (CDRD), Vancouver, BC, Canada.
  • Vitko N; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Richardson AR; Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Zoraghi R; Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, BC, Canada.
  • Young RN; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada. Electronic address: robert_young@sfu.ca.
Bioorg Med Chem ; 22(5): 1708-25, 2014 Mar 01.
Article em En | MEDLINE | ID: mdl-24508307
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Staphylococcus aureus Resistente à Meticilina Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Staphylococcus aureus Resistente à Meticilina Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article