Direct oral anticoagulants in the treatment and long-term prevention of venous thrombo-embolism.
Eur Heart J
; 35(28): 1836-43, 2014 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-24510637
ABSTRACT
Direct oral anticoagulants (DOACs) specifically target factor IIa or Xa and represent a major step forward in the treatment of acute- and long-term prevention of venous thrombo-embolism (VTE). They are at least as effective and as safe as conventional therapy (heparins and vitamin-K inhibitors) and have practical advantages, such as fixed dosing and no need for laboratory monitoring. These antithrombotic agents introduce a new paradigm for the day-to-day management of VTE. Direct oral anticoagulants should streamline the management of most patients with VTE and will facilitate care in the outpatient setting. Nevertheless, it remains uncertain how to select specific DOACs for particular profiles of patients, and the optimal management of bleeding complications is evolving.
Palavras-chave
Texto completo:
1
Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Antitrombinas
/
Tromboembolia Venosa
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article