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Dangers of "confirmatory" cancer trials that fail to actually test the original hypothesis.
Markman, Maurie.
Afiliação
  • Markman M; Cancer Treatment Centers of America, Philadelphia, PA, USA, Maurie.Markman@ctca-hope.com.
Curr Oncol Rep ; 16(4): 381, 2014 Apr.
Article em En | MEDLINE | ID: mdl-24510743
The concept of "confirmatory" studies is a standard and important component of the overall clinical trials strategy in oncology. However, it is critical that such studies are similar enough in basic design and how they are conducted that they actually have the realistic potential to confirm, or refute, objectively the findings of the original study. In this commentary, two examples of clinical studies in the gynecologic oncology arena suggested by some to serve as "confirmatory" trials for the original reports demonstrate both the dangers and potential inappropriateness of such conclusions.
Assuntos

Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Ensaios Clínicos Controlados Aleatórios como Assunto Tipo de estudo: Clinical_trials Limite: Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Ensaios Clínicos Controlados Aleatórios como Assunto Tipo de estudo: Clinical_trials Limite: Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article