Peptide specificities of myelin basic protein-reactive human T-cell clones.
Neurology
; 38(5): 739-42, 1988 May.
Article
em En
| MEDLINE
| ID: mdl-2452382
Forty myelin basic protein (BP)-reactive T-cell clones were isolated from a patient with multiple sclerosis and used to identify human T-cell recognition sites on the BP molecule. At least three sites have been identified: one in the N-terminal half of the molecule (residues 1-97), one in the C-terminal (residues 98-170), and one which spans residues 97-98. The clones exhibited a marked preference for the C-terminal half of the molecule. No cross-reactivity with measles virus was detected. These clones will be useful for both the further delineation of the human T-cell recognition sites on BP and the generation of anticlonotypic monoclonal antibodies.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Linfócitos T
/
Proteína Básica da Mielina
/
Epitopos
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article