Rapid resolution of protracted febrile myalgia syndrome with anakinra: Report of two cases.
Mod Rheumatol
; 26(3): 458-9, 2016.
Article
em En
| MEDLINE
| ID: mdl-24533541
ABSTRACT
Protracted febrile myalgia syndrome (PFMS) is a very rare but severe manifestation of familial Mediterranean fever (FMF) which is characterized by severe debilitating pain in large muscle groups that may last for several weeks. Colchicine is ineffective and treatment is largely supportive. Demonstration of crucial role of interleukin-1 (IL-1) in the pathogenesis of FMF has increased the use of IL-1 blockers in colchicine resistant or intolerant patients. Herein, we reported successful use of an IL-1 inhibitor, anakinra, in treatment of two patients with PFMS.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Febre Familiar do Mediterrâneo
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Proteína Antagonista do Receptor de Interleucina 1
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Mialgia
Tipo de estudo:
Etiology_studies
Limite:
Adult
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Female
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article