Influences of dopamine and glutamate in the medial preoptic area on male sexual behavior.
Pharmacol Biochem Behav
; 121: 115-23, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24534416
ABSTRACT
Several brain nuclei interact to orchestrate the appetitive and consummatory aspects of male sexual behavior. Of these structures, the medial preoptic area (mPOA) of the hypothalamus is of particular interest, as it receives input from all sensory modalities, and damage to this region disrupts copulation in a wide variety of taxa. Furthermore, the mPOA is both responsive to gonadal hormones and involved in endocrine regulation. Neurochemical studies have demonstrated that both dopamine and glutamate levels rise in the mPOA in response to sexual activity, while antagonism of these neurotransmitters impairs male sexual response. Here we review how dopamine and glutamate act in the mPOA to modulate male sexual behavior.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Área Pré-Óptica
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Comportamento Sexual Animal
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Dopamina
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Ácido Glutâmico
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article