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Taro corms mucilage/HPMC based transdermal patch: an efficient device for delivery of diltiazem hydrochloride.
Sarkar, Gunjan; Saha, Nayan Ranjan; Roy, Indranil; Bhattacharyya, Amartya; Bose, Madhura; Mishra, Roshnara; Rana, Dipak; Bhattacharjee, Debashis; Chattopadhyay, Dipankar.
Afiliação
  • Sarkar G; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
  • Saha NR; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
  • Roy I; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
  • Bhattacharyya A; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
  • Bose M; Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
  • Mishra R; Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
  • Rana D; Department of Chemical and Biological Engineering, Industrial Membrane Research Institute, University of Ottawa, 161 Louis Pasteur St., Ottawa, ON, K1N 6N5, Canada.
  • Bhattacharjee D; Swasthya Bhavan, Department of Health and Family Welfare, Government of West Bengal, Salt Lake, Kolkata 700091, India.
  • Chattopadhyay D; Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India. Electronic address: dipankar.chattopadhyay@gmail.com.
Int J Biol Macromol ; 66: 158-65, 2014 May.
Article em En | MEDLINE | ID: mdl-24556117
ABSTRACT
The aim of this work is to examine the effectiveness of mucilage/hydroxypropylmethylcellulose (HPMC) based transdermal patch (matrix type) as a drug delivery device. We have successfully extracted mucilage from Colocasia esculenta (Taro) corms and prepared diltiazem hydrochloride incorporated mucilage/HPMC based transdermal patches using various wt% of mucilage by the solvent evaporation technique. Characterization of both mucilage and transdermal patches has been done by several techniques such as Molisch's test, organoleptic evaluation of mucilage, mechanical, morphological and thermal analysis of transdermal patches. Skin irritation test is studied on hairless Albino rat skin showing that transdermal patches are apparently free of potentially hazardous skin irritation. Fourier transform infrared analysis shows that there is no interaction between drug, mucilage and HPMC while scanning electron microscopy shows the surface morphology of transdermal patches. In vitro drug release time of mucilage-HPMC based transdermal patches is prolonged with increasing mucilage concentration in the formulation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Diltiazem / Colocasia / Adesivo Transdérmico / Mucilagem Vegetal Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Diltiazem / Colocasia / Adesivo Transdérmico / Mucilagem Vegetal Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article