Risk factors for critical disease and death from hand, foot and mouth disease.
Pediatr Infect Dis J
; 33(9): 966-70, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24577041
ABSTRACT
BACKGROUND:
There has been a high mortality and morbidity rate of critical and fatal patients from hand, foot and mouth disease (HFMD) in China in recent. Causes for development of critical and fatal disease remain unclear.METHODS:
We performed a case-control study to assess the association between use of drugs and development of critical disease and death from HFMD.RESULTS:
We found that glucocorticoids treatment was associated with a greater incidence of severe HFMD, whereas andrographolides treatment was associated with a protective effect when they are used for treatment within 48 hours after onset or before being diagnosed as critical.CONCLUSIONS:
We recommend that glucocorticoids should not be used for mild HFMD and andrographolides should undergo clinical trials for treatment of enterovirus 71 infections.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glucocorticoides
/
Doença de Mão, Pé e Boca
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article