[Chronic obstructive pulmonary disease (COPD). Current concepts and new therapeutic options]. / Die chronisch-obstruktive Lungenerkrankung (COPD). Aktuelle Konzepte und neue Therapieoptionen.

ABSTRACT

Chronic obstructive pulmonary disease (COPD) is a very common chronic disease with increasing prevalence. Inhaled particles and gases (in particular tobacco smoke) induce chronic inflammation of the airways accompanied by a not fully reversible airflow limitation. Destruction of lung tissue and deterioration of gas exchange may follow. In parallel, several comorbidities can be observed. The COPD assessment was revised and now takes into account lung function, the patients' symptoms, and history of exacerbations. More recently, several new long-acting bronchodilators received approval. Combination products, consisting of long-acting ß2-agonists and long-acting anticholinergics, and a new combination of a long-acting ß-agonist and an inhaled corticosteroid will follow in the near future. Smoking cessation is of central importance.