[Interleukin-32 expression in serum of patients with HBV-related liver failure and its significance].
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
; 27(4): 247-9, 2013 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-24579465
ABSTRACT
OBJECTIVE:
To investigate the expression level of IL-32 in serum and its correlation with serum biochemical indices of liver function test and HBV DNA load in patients with HBV-related liver failure.METHODS:
Fifty-five patients with HBV-related liver failure (severe hepatitis group) and twenty normal cases (control group) were enrolled in the study. Total RNA in PBMCs was extracted by using TRIzol. IL-32 mRNA level was assayed by using Real-time PCR. IL-32 protein level in serum was detected by ELSIA method. The correlation between IL-32 and ALT, AST, TBIL, HBV DNA load was analyzed using pearson's correlation analysis, respectively.RESULTS:
Serum IL-32 expression level in severe hepatitis group was higher than that of control group. Moreover, the difference between them was statistically significant (P < 0.05). Serum IL-32 level was positively correlated with serum ALT, AST, TBIL, respectively (P < 0.05), but was not correlated with HBV DNA load (P > 0.05).CONCLUSION:
Serum IL-32 expression level was increased in patients with HBV-related liver failure and was associated with the severity of inflammation. We, therefore, believe that IL-32 might be involved in the pathogenesis of HBV-related liver failure.
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Base de dados:
MEDLINE
Assunto principal:
Interleucinas
/
Falência Hepática
/
Hepatite B Crônica
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article