The synthesis and strecker reaction of 2-chlorotetrafluoroethanesulfinyl ketimines.
J Org Chem
; 79(7): 3215-20, 2014 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-24597652
ABSTRACT
A series of 2-chlorotetrafluoroethanesulfinyl ketimines were prepared from 2-chlorotetrafluoroethanesulfinamide and ketones in high yields, and their Strecker reactions with TMSCN have been investigated. High yields and excellent diastereoselectivities were achieved in the presence of a catalytic amount of CsF under mild conditions. The six-membered chairlike models were proposed to account for the high stereoselective Strecker reaction.
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MEDLINE
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En
Ano de publicação:
2014
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Article