Design, synthesis and biological evaluation of new inhibitors of Bax/Bcl-xL interaction in cancer cells.
Bioorg Med Chem Lett
; 24(7): 1758-61, 2014 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-24602902
ABSTRACT
We describe the synthesis of a series of new molecules containing phenol and triazoles moieties, compounds which have been evaluated for their ability to inhibit Bax/Bcl-xL interactions in cancer cells, by using BRET assays, and to induce cell death. Several derivatives exhibit a very promising activity, being more potent than the reference compounds acylpyrogallol A and ABT-737. These preliminary results demonstrate that derivatives of this family can be attractive to develop new molecules with potent anticancer activity.
Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Triazóis
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Desenho de Fármacos
/
Proteína X Associada a bcl-2
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Proteína bcl-X
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article