Adenosine-5'-triphosphate-sensitive ion channels in neonatal rat cultured central neurones.
Pflugers Arch
; 412(3): 297-304, 1988 Aug.
Article
em En
| MEDLINE
| ID: mdl-2460821
ABSTRACT
ATP-sensitive channels were observed in isolated inside-out membrane patches from rat cultured central neurones. Two types of ATP-sensitive K+ channels were present in cortical neurones, one which had its open-state probability increased, the other its open-state probability decreased by application of ATP to the cytoplasmic membrane surface. Another, ATP-sensitive channel differing in ion conductance from all previously reported ATP-sensitive channels was also seen in patches from cortical neurones. This channel was nonselective with respect to Na+, K+ and Cl- ions and ATP produced a "flickery" type of block. The non-hydrolysable analogue, AMPPNP, did not mimic ATP and prevented ATP action. Preliminary experiments indicate that similar, but not, identical ATP-sensitive channels exist in cerebellar neurones.
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Base de dados:
MEDLINE
Assunto principal:
Cerebelo
/
Córtex Cerebral
/
Trifosfato de Adenosina
/
Canais Iônicos
/
Animais Recém-Nascidos
/
Neurônios
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article