Peripheral CD4+ cell prevalence and pleuropulmonary manifestations in systemic lupus erythematosus patients.
Respir Med
; 108(5): 766-74, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24613209
ABSTRACT
INTRODUCTION:
Systemic lupus erythematosus (SLE) is an autoimmune disease involving several organs, including the lungs. Previous results confirmed changes of peripheral T cell subsets in lupus patients; however no data are available about their possible relationship with pulmonary involvement.OBJECTIVE:
To determine pulmonary manifestations and potential relationship in changes of peripheral CD4+ T cell subsets.METHODS:
Patients with SLE (N = 28) were enrolled in complex pulmonary examination. Patients were divided into groups with pleuropulmonary manifestations (SLEpulm N = 13 age 44.9 ± 3.3 years, female male = 112) or without (SLEc N = 15 age 27.2 ± 3.7 years, female male = 123). Peripheral blood was taken for T helper (Th)1, Th2, Th17, CD4+CD25hi+ and regulatory T (Treg CD4+CD25hi+ CD127-) cell analysis from SLE patients and healthy volunteers (controls, N = 40).RESULTS:
SLEpulm patients were older, had more pulmonary symptoms and significantly decreased pO2 as compared to SLEc group. Ventilatory disorder was present in 92% of SLEpulm patients, with significantly decreased lung volumes, signs of airway involvement and decrease in DLco. Significant increase in Th1/Th2, while decrease in Th17/Treg ratios was present in all SLE compared to controls. In SLEpulm CD4+CD25hi+ subset without changes in Treg number was significantly increased as compared to SLEc and this subgroup of T cell showed significant positive correlation with dynamic lung function parameters and DLco (p < 0.05).CONCLUSION:
In lupus patients pleuropulmonary manifestations are prevalent and lung function and blood gas measurements should be regularly performed in the daily clinical assessment. Significant increase of activated CD4+CD25hi+ T cells, but not Treg is associated with decreased lung function parameters in SLEpulm patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
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Pneumopatias
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Lúpus Eritematoso Sistêmico
Tipo de estudo:
Etiology_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article