Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain.

Cohen-Kutner, Moshe; Khomsky, Lena; Trus, Michael; Ben-Yehuda, Hila; Lenhard, James M; Liang, Yin; Martin, Tonya; Atlas, Daphne

Cohen-Kutner, Moshe; Khomsky, Lena; Trus, Michael; Ben-Yehuda, Hila; Lenhard, James M; Liang, Yin; Martin, Tonya; Atlas, Daphne.

Afiliação

Cohen-Kutner M; Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904 Israel.
Khomsky L; Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904 Israel.
Trus M; Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904 Israel.
Ben-Yehuda H; Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904 Israel.
Lenhard JM; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC of Johnson and Johnson, Welsh and McKean Roads, Springhouse, PA 19477, USA.
Liang Y; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC of Johnson and Johnson, Welsh and McKean Roads, Springhouse, PA 19477, USA.
Martin T; Cardiovascular and Metabolic Research, Janssen Research & Development, LLC of Johnson and Johnson, Welsh and McKean Roads, Springhouse, PA 19477, USA.
Atlas D; Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904 Israel.

Redox Biol ; 2: 447-56, 2014.

Article em En | MEDLINE | ID: mdl-24624334

Assuntos

Encéfalo/metabolismo; Diabetes Mellitus Tipo 2/tratamento farmacológico; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Obesidade/tratamento farmacológico; Oligopeptídeos/administração & dosagem; Peptidomiméticos/administração & dosagem; Compostos de Sulfidrila/administração & dosagem; Animais; Glicemia/metabolismo; Linhagem Celular Tumoral; Diabetes Mellitus Tipo 2/metabolismo; Modelos Animais de Doenças; Humanos; Insulina/sangue; Masculino; Obesidade/metabolismo; Oligopeptídeos/farmacologia; Estresse Oxidativo/efeitos dos fármacos; Peptidomiméticos/farmacologia; Fosforilação; Ratos; Ratos Zucker; Compostos de Sulfidrila/farmacologia

Palavras-chave

AICAR, 5-amino-4-imidazole carboxamide riboside; AMPK; AMPK, AMP-activated protein kinase; Ad-AMPK-CA, AMPK-constitutively active AMP-activated protein kinase mutants; CB3; CB3, NAc-Cys-Pro Cys-amide, TXM-CB3; Diabetes type 2; Inflammation; MAPK; Oxidative stress; Redox; TXNIP/TBP-2; TXNIP/TBP-2, thioredoxin-interacting protein; Thioredoxin mimetics; ZDF rat-model

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Compostos de Sulfidrila / Encéfalo / Sistema de Sinalização das MAP Quinases / Diabetes Mellitus Tipo 2 / Peptidomiméticos / Obesidade Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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