Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation.

Chan, Amy J; Alikhan, Maliha A; Odobasic, Dragana; Gan, Poh Y; Khouri, Mary B; Steinmetz, Oliver M; Mansell, Ashley S; Kitching, A Richard; Holdsworth, Stephen R; Summers, Shaun A

Chan, Amy J; Alikhan, Maliha A; Odobasic, Dragana; Gan, Poh Y; Khouri, Mary B; Steinmetz, Oliver M; Mansell, Ashley S; Kitching, A Richard; Holdsworth, Stephen R; Summers, Shaun A.

Afiliação

Chan AJ; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia.
Alikhan MA; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia.
Odobasic D; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia.
Gan PY; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia.
Khouri MB; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia.
Steinmetz OM; Department of Internal Medicine III and Clinics, Hamburg-Eppendorf University Clinic, Hamburg, Germany.
Mansell AS; Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Victoria, Australia.
Kitching AR; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia; Department of Nephrology, Monash Health, Victoria, Australia.
Holdsworth SR; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia; Department of Nephrology, Monash Health, Victoria, Australia. Electronic address: stephen.holdsworth@monash.edu.
Summers SA; Department of Medicine, Centre for Inflammatory Diseases, Monash University, Victoria, Australia; Department of Nephrology, Monash Health, Victoria, Australia.

Am J Pathol ; 184(5): 1411-8, 2014 May.

Article em En | MEDLINE | ID: mdl-24631024

Assuntos

Injúria Renal Aguda/patologia; Inflamassomos/metabolismo; Interleucina-17/biossíntese; Leucócitos/metabolismo; Receptor 2 Toll-Like/metabolismo; Injúria Renal Aguda/induzido quimicamente; Injúria Renal Aguda/genética; Animais; Anticorpos/farmacologia; Proteínas Reguladoras de Apoptose/metabolismo; Proteínas Adaptadoras de Sinalização CARD; Linfócitos T CD4-Positivos/efeitos dos fármacos; Linfócitos T CD4-Positivos/imunologia; Quimiocinas/genética; Quimiocinas/metabolismo; Cisplatino/efeitos adversos; Regulação da Expressão Gênica/efeitos dos fármacos; Inflamassomos/efeitos dos fármacos; Interleucina-17/genética; Interleucina-17/metabolismo; Rim/metabolismo; Rim/patologia; Células Matadoras Naturais/efeitos dos fármacos; Células Matadoras Naturais/imunologia; Leucócitos/efeitos dos fármacos; Masculino; Camundongos Endogâmicos C57BL; Infiltração de Neutrófilos/efeitos dos fármacos; Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interleucina-17 / Receptor 2 Toll-Like / Injúria Renal Aguda / Inflamassomos / Leucócitos Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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