Effect of simvastatin on the resistance to EGFR tyrosine kinase inhibitors in a non-small cell lung cancer with the T790M mutation of EGFR.

Hwang, Ki-Eun; Kwon, Su-Jin; Kim, Young-Suk; Park, Do-Sim; Kim, Byoung-Ryun; Yoon, Kwon-Ha; Jeong, Eun-Taik; Kim, Hak-Ryul

Hwang, Ki-Eun; Kwon, Su-Jin; Kim, Young-Suk; Park, Do-Sim; Kim, Byoung-Ryun; Yoon, Kwon-Ha; Jeong, Eun-Taik; Kim, Hak-Ryul.

Afiliação

Hwang KE; Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University, School of Medicine, 344-2 shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea.
Kwon SJ; Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University, School of Medicine, 344-2 shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea.
Kim YS; Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University, School of Medicine, 344-2 shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea.
Park DS; Department of Laboratory Medicine, Wonkwang University, School of Medicine, Iksan, Republic of Korea.
Kim BR; Department of Obstetrics & Gynecology, Wonkwang University, School of Medicine, Iksan, Republic of Korea.
Yoon KH; Department of Radiology, Wonkwang University, School of Medicine, Iksan, Republic of Korea.
Jeong ET; Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University, School of Medicine, 344-2 shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea.
Kim HR; Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University, School of Medicine, 344-2 shinyong-dong, Iksan, Jeonbuk 570-749, Republic of Korea. Electronic address: kshryj@wonkwang.ac.kr.

Exp Cell Res ; 323(2): 288-96, 2014 May 01.

Article em En | MEDLINE | ID: mdl-24631288

Assuntos

Antineoplásicos/farmacologia; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Resistencia a Medicamentos Antineoplásicos; Receptores ErbB/antagonistas & inibidores; Inibidores de Proteínas Quinases/farmacologia; Quinazolinas/farmacologia; Sinvastatina/farmacologia; Apoptose/efeitos dos fármacos; Cateninas/genética; Cateninas/metabolismo; Linhagem Celular Tumoral; Receptores ErbB/genética; Gefitinibe; Humanos; Proteínas Inibidoras de Apoptose/genética; Proteínas Inibidoras de Apoptose/metabolismo; Mutação de Sentido Incorreto; Survivina

Palavras-chave

EGFR tyrosine kinase inhibitors; Lung cancer; Resistance; Simvastatin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Carcinoma Pulmonar de Células não Pequenas / Resistencia a Medicamentos Antineoplásicos / Sinvastatina / Inibidores de Proteínas Quinases / Receptores ErbB / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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