Your browser doesn't support javascript.
loading
Time-dependent changes in atherosclerotic plaque composition in patients undergoing carotid surgery.
van Lammeren, Guus W; den Ruijter, Hester M; Vrijenhoek, Joyce E P; van der Laan, Sander W; Velema, Evelyn; de Vries, Jean-Paul P M; de Kleijn, Dominique P V; Vink, Aryan; de Borst, Gert Jan; Moll, Frans L; Bots, Michiel L; Pasterkamp, Gerard.
Afiliação
  • van Lammeren GW; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • den Ruijter HM; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • Vrijenhoek JE; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • van der Laan SW; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • Velema E; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • de Vries JP; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • de Kleijn DP; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • Vink A; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • de Borst GJ; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • Moll FL; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • Bots ML; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
  • Pasterkamp G; From the Experimental Cardiology Laboratory (G.W.v.L., H.M.d.R., J.E.P.V., S.W.v.d.L., E.V., D.P.V.d.K., G.P.), Departments of Vascular Surgery (G.W.v.L., J.E.P.V., G.J.d.B., F.L.M.) and Pathology (A.V.), and Julius Center for Health Sciences and Primary Care (H.M.d.R., M.L.B.), University Medical C
Circulation ; 129(22): 2269-76, 2014 Jun 03.
Article em En | MEDLINE | ID: mdl-24637558
ABSTRACT

BACKGROUND:

Time-dependent trends in the incidence of cardiovascular disease have been reported in high-income countries. Because atherosclerosis underlies the majority of cardiovascular diseases, we investigated temporal changes in the composition of atherosclerotic plaques removed from patients undergoing carotid endarterectomy. METHODS AND

RESULTS:

The Athero-Express study is an ongoing, longitudinal, vascular biobank study that includes the collection of atherosclerotic plaques of patients undergoing primary carotid endarterectomy in the province of Utrecht from 2002 to 2011. Histopathologic features of plaques of 1583 patients were analyzed in intervals of 2 years. The analysis included quantification of collagen, calcifications, lipid cores, plaque thrombosis, macrophages, smooth muscle cells, and microvessels. Large atheroma, plaque thrombosis, macrophages, and calcifications were less frequently observed over time, with adjusted odds ratios of 0.72 (95% confidence interval, 0.650-0.789), 0.62 (95% confidence interval, 0.569-0.679), 0.87 (95% confidence interval, 0.800-0.940), and 0.75 (95% confidence interval, 0.692-0.816) per 2-year increase in time, respectively. These changes in plaque characteristics were consistently observed in patient subgroups presenting with stroke, transient ischemic attack, ocular symptoms, and asymptomatic patients. Concomitantly, risk factor management and secondary prevention strategies among vascular patients scheduled for carotid endarterectomy significantly improved over the past decade.

CONCLUSIONS:

In conclusion, over the past decade, atherosclerotic plaques harvested during carotid endarterectomy show a time-dependent change in plaque composition characterized by a decrease in features currently believed to be causal for plaque instability. This appears to go hand in hand with improvements in risk factor management.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças das Artérias Carótidas / Endarterectomia das Carótidas / Placa Aterosclerótica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças das Artérias Carótidas / Endarterectomia das Carótidas / Placa Aterosclerótica Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2014 Tipo de documento: Article