BikDDA, a mutant of Bik with longer half-life expression protein, can be a novel therapeutic gene for triple-negative breast cancer.

Jiao, Shiping; Wu, Minqing; Ye, Feng; Tang, Hailin; Xie, Xinhua; Xie, Xiaoming

Jiao, Shiping; Wu, Minqing; Ye, Feng; Tang, Hailin; Xie, Xinhua; Xie, Xiaoming.

Afiliação

Jiao S; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China; Zhongshan School of Medicine, Sun
Wu M; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China; Department of Cancer Prevention Center, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
Ye F; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
Tang H; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
Xie X; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
Xie X; Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.

PLoS One ; 9(3): e92172, 2014.

Article em En | MEDLINE | ID: mdl-24637719

Assuntos

Proteínas Reguladoras de Apoptose/genética; Proteínas de Membrana/genética; Terapia de Alvo Molecular; Proteínas Mutantes/genética; Neoplasias de Mama Triplo Negativas/genética; Neoplasias de Mama Triplo Negativas/terapia; Apoptose; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Quimioterapia Adjuvante; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; MAP Quinases Reguladas por Sinal Extracelular; Feminino; Fluoruracila/farmacologia; Fluoruracila/uso terapêutico; Meia-Vida; Humanos; Pessoa de Meia-Idade; Proteínas Mitocondriais; Análise Multivariada; Proteína de Sequência 1 de Leucemia de Células Mieloides/metabolismo; Fosforilação/efeitos dos fármacos; Prognóstico; Neoplasias de Mama Triplo Negativas/enzimologia; Neoplasias de Mama Triplo Negativas/cirurgia; Proteína bcl-X/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Reguladoras de Apoptose / Proteínas Mutantes / Terapia de Alvo Molecular / Neoplasias de Mama Triplo Negativas / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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