Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells.
J Microencapsul
; 31(5): 501-7, 2014.
Article
em En
| MEDLINE
| ID: mdl-24654943
ABSTRACT
CONTEXT Celastrol, a natural compound derived from the herb Tripterygium wilfordii, is known to have anticancer activity, but is not soluble in water. OBJECTIVE:
Formation of celastrol liposomes, to avoid the use of toxic solubilising agents. MATERIALS ANDMETHODS:
Two different formulations of PEGylated celastrol liposomes were fabricated. Liposomal characteristics and serum stability were determined using dynamic light scattering. Drug entrapment efficacy and drug release were measured spectrophotometrically. Cellular internalisation and anticancer activity was measured in prostate cancer cells.RESULTS:
Liposomal celastrol displayed efficient serum stability, cellular internalisation and anticancer activity, comparable to that of the free drug reconstituted in dimethyl sulfoxide. DISCUSSION ANDCONCLUSION:
Liposomal celastrol can decrease the viability of prostate cancer cells, while eliminating the need for toxic solubilising agents.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Triterpenos
/
Tripterygium
/
Antineoplásicos Fitogênicos
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article