Systems-level analysis of innate immunity.
Annu Rev Immunol
; 32: 547-77, 2014.
Article
em En
| MEDLINE
| ID: mdl-24655298
ABSTRACT
Systems-level analysis of biological processes strives to comprehensively and quantitatively evaluate the interactions between the relevant molecular components over time, thereby enabling development of models that can be employed to ultimately predict behavior. Rapid development in measurement technologies (omics), when combined with the accessible nature of the cellular constituents themselves, is allowing the field of innate immunity to take significant strides toward this lofty goal. In this review, we survey exciting results derived from systems biology analyses of the immune system, ranging from gene regulatory networks to influenza pathogenesis and systems vaccinology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia de Sistemas
/
Imunidade Inata
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article