Transcripts of the insulin-like growth factors I and II in human hepatoma.
Cancer Res
; 49(7): 1773-7, 1989 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-2466561
ABSTRACT
Using complementary DNAs of human insulin-like growth factors as probes, expressions of the insulin-like growth factors I and II mRNA were examined in seven human hepatoma tissues and their adjacent nontumorous livers. The level of insulin-like growth factor I mRNA in hepatoma was lower than that in the nontumorous liver control. This phenomenon was probably caused by the low expression of human growth hormone receptor in hepatoma tissues. The levels of insulin-like growth factor II mRNA vary among hepatomas. Some show elevated expression; some have diminished expression compared to their nontumorous liver counterparts. In four of the seven hepatomas, expression of fetal forms of insulin-like growth factor II transcripts was observed and may represent dedifferentiation of insulin-like growth factor II expression during hepatocarcinogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Somatomedinas
/
Fator de Crescimento Insulin-Like I
/
Fator de Crescimento Insulin-Like II
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Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article