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Human chorionic gonadotropin discriminatory zone in ectopic pregnancy: does assay harmonization matter?
Desai, Diana; Lu, Jun; Wyness, Sara P; Greene, Dina N; Olson, Kalen N; Wiley, Carmen L; Grenache, David G.
Afiliação
  • Desai D; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah.
  • Lu J; ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah.
  • Wyness SP; ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah.
  • Greene DN; Northern California Kaiser Permanente Regional Laboratory, Berkeley, California.
  • Olson KN; HealthPartners/Regions Hospital, St. Paul, Minnesota.
  • Wiley CL; PAML, Spokane, Washington.
  • Grenache DG; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah; ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah. Electronic address: david.grenache@path.utah.edu.
Fertil Steril ; 101(6): 1671-4, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24666754
OBJECTIVE: To determine the effect that lack of hCG assay harmonization has on the interpretation of a serum hCG concentration with regards to the hCG discriminatory zone. DESIGN: A multisite method comparison study. SETTING: Clinical laboratories. PATIENT(S): Eighty serum samples containing various concentrations of hCG. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Concentrations of hCG obtained from seven hCG reagent platforms. RESULT(S): The hCG concentrations were significantly different across hCG reagent platforms. Seventy-one percent of assay pairs showed significant differences with samples selected based on hCG concentrations between 1,500 and 3,500 IU/L as determined by a comparative method. Relative to the comparative method, the calculated hCG discriminatory zones for five assays were within 9%, and one assay was within 40% of the target concentrations of 1,500 and 3,500 IU/L. CONCLUSION(S): Despite significant differences in hCG concentrations across hCG immunoassays, an hCG concentration within a discriminatory zone of 1,500-3,500 IU/L can be used for all but one commonly used hCG reagent platform.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gravidez Ectópica / Técnicas de Laboratório Clínico / Gonadotropina Coriônica Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Female / Humans / Pregnancy País como assunto: America do norte Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gravidez Ectópica / Técnicas de Laboratório Clínico / Gonadotropina Coriônica Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Female / Humans / Pregnancy País como assunto: America do norte Idioma: En Ano de publicação: 2014 Tipo de documento: Article