Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential.

Klinkhammer, Barbara Mara; Kramann, Rafael; Mallau, Monika; Makowska, Anna; van Roeyen, Claudia Renate; Rong, Song; Buecher, Eva Bettina; Boor, Peter; Kovacova, Katarina; Zok, Stephanie; Denecke, Bernd; Stuettgen, Esther; Otten, Simon; Floege, Juergen; Kunter, Uta

Klinkhammer, Barbara Mara; Kramann, Rafael; Mallau, Monika; Makowska, Anna; van Roeyen, Claudia Renate; Rong, Song; Buecher, Eva Bettina; Boor, Peter; Kovacova, Katarina; Zok, Stephanie; Denecke, Bernd; Stuettgen, Esther; Otten, Simon; Floege, Juergen; Kunter, Uta.

Afiliação

Klinkhammer BM; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Kramann R; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Mallau M; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Makowska A; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
van Roeyen CR; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Rong S; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Buecher EB; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Boor P; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia.
Kovacova K; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Zok S; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Denecke B; Interdisciplinary Centre for Clinical Research, RWTH Aachen University Hospital, Aachen, Germany.
Stuettgen E; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Otten S; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Floege J; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.
Kunter U; Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany.

PLoS One ; 9(3): e92115, 2014.

Article em En | MEDLINE | ID: mdl-24667162

Assuntos

Senescência Celular/fisiologia; Glomérulos Renais/patologia; Células-Tronco Mesenquimais/citologia; Nefrite/patologia; Regeneração/fisiologia; Insuficiência Renal Crônica/patologia; Animais; Western Blotting; Células Cultivadas; Meios de Cultivo Condicionados/farmacologia; Citocinas/genética; Citocinas/metabolismo; Modelos Animais de Doenças; Fibroblastos/citologia; Humanos; Técnicas Imunoenzimáticas; Peptídeos e Proteínas de Sinalização Intercelular/genética; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Masculino; Transplante de Células-Tronco Mesenquimais; Nefrite/imunologia; Nefrite/terapia; RNA Mensageiro/genética; Ratos; Ratos Endogâmicos F344; Reação em Cadeia da Polimerase em Tempo Real; Insuficiência Renal Crônica/terapia; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Antígenos Thy-1/imunologia; Doadores de Tecidos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regeneração / Senescência Celular / Insuficiência Renal Crônica / Células-Tronco Mesenquimais / Glomérulos Renais / Nefrite Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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