[Molecular biology in myelodysplastic syndromes and acute myeloid leukemias "smoldering"]. / Biologia molecolare nelle sindromi mielodisplastiche e nelle leucemie acute mieloidi "smoldering"
Recenti Prog Med
; 105(3): 118-22, 2014 Mar.
Article
em It
| MEDLINE
| ID: mdl-24675454
ABSTRACT
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders of the myeloid lineage characterized by peripheral cytopenias and frequent leukemic evolution. MDS differ for clinical presentation, disease behavior and progression and this is the reflection of remarkable variability at molecular level. To this moment disease diagnosis is still dependent on bone marrow morphology that, although high concordance rates among experts are reported, remains subjective. Karyotype analysis is mandatory but diagnosis may be difficult in presence of normal karyotype or non-informative cytogenetics. Standardized molecular markers are needed to better define diagnosis, prediction of disease progression and prognosis. Furthermore, a molecular biology analysis could provide an important therapeutic tool towards tailored therapy and new insights in the disease's biology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Leucemia Mieloide Aguda
/
Biologia Molecular
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
It
Ano de publicação:
2014
Tipo de documento:
Article