The Geogenomic Mutational Atlas of Pathogens (GoMAP) web system.
PLoS One
; 9(3): e92877, 2014.
Article
em En
| MEDLINE
| ID: mdl-24675726
ABSTRACT
We present a new approach for pathogen surveillance we call Geogenomics. Geogenomics examines the geographic distribution of the genomes of pathogens, with a particular emphasis on those mutations that give rise to drug resistance. We engineered a new web system called Geogenomic Mutational Atlas of Pathogens (GoMAP) that enables investigation of the global distribution of individual drug resistance mutations. As a test case we examined mutations associated with HIV resistance to FDA-approved antiretroviral drugs. GoMAP-HIV makes use of existing public drug resistance and HIV protein sequence data to examine the distribution of 872 drug resistance mutations in â¼ 502,000 sequences for many countries in the world. We also implemented a broadened classification scheme for HIV drug resistance mutations. Several patterns for geographic distributions of resistance mutations were identified by visual mining using this web tool. GoMAP-HIV is an open access web application available at http//www.bio-toolkit.com/GoMap/project/
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vigilância da População
/
Doenças Transmissíveis
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Genômica
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Bases de Dados Genéticas
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Genoma Microbiano
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Navegador
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Mutação
Tipo de estudo:
Prognostic_studies
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Screening_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article