Combined heterogeneous metal/chiral amine: multiple relay catalysis for versatile eco-friendly synthesis.
Angew Chem Int Ed Engl
; 53(13): 3447-51, 2014 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-24677482
ABSTRACT
Herein is described a versatile and broad synergistic strategy for expansion of chemical space and the synthesis of valuable molecules (e.g. carbocycles and heterocycles), with up to three quaternary stereocenters, in a highly enantioselective fashion from simple alcohols (31 examples, 955 to >99.50.5 e.r.) using integrated heterogeneous metal/chiral amine multiple relay catalysis and air/O2 as the terminal oxidant. A novel highly 1,4-selective heterogeneous metal/amine co-catalyzed hydrogenation of enals was also added to the relay catalysis sequences.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article