Nonracemic synthesis of GK-GKRP disruptor AMG-3969.
J Org Chem
; 79(8): 3684-7, 2014 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-24678849
ABSTRACT
A nonracemic synthesis of the glucokinase-glucokinase regulatory protein disruptor AMG-3969 (5) is reported. Key features of the synthetic approach are an asymmetric synthesis of the 2-alkynyl piperazine core via a base-promoted isomerization and a revised approach to the synthesis of the aminopyridinesulfonamide with an improved safety profile.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Piridinas
/
Sulfonamidas
/
Compostos de Benzil
/
Carbamatos
/
Proteínas de Transporte
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article