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The immunomodulatory effects of pegylated liposomal doxorubicin are amplified in BRCA1--deficient ovarian tumors and can be exploited to improve treatment response in a mouse model.
Mantia-Smaldone, Gina; Ronner, Lukas; Blair, Anne; Gamerman, Victoria; Morse, Christopher; Orsulic, Sandra; Rubin, Stephen; Gimotty, Phyllis; Adams, Sarah.
Afiliação
  • Mantia-Smaldone G; Section of Gynecologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Electronic address: gina.mantia-smaldone@fccc.edu.
  • Ronner L; Division of Gynecologic Oncology, Hospital of the University of Pennsylvania, 3rd Floor, PCAM, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
  • Blair A; Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 501 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.
  • Gamerman V; Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 501 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.
  • Morse C; Division of Gynecologic Oncology, Hospital of the University of Pennsylvania, 3rd Floor, PCAM, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
  • Orsulic S; Women's Cancer Research Institute at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Rubin S; Section of Gynecologic Oncology, Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
  • Gimotty P; Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 501 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA.
  • Adams S; Division of Gynecologic Oncology, University of New Mexico Cancer Center, 1201 Camino de Salud NE, 1 University of New Mexico, Albuquerque, NM 87106, USA.
Gynecol Oncol ; 133(3): 584-90, 2014 Jun.
Article em En | MEDLINE | ID: mdl-24680909
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Linfócitos T / Doxorrubicina / Linfócitos do Interstício Tumoral / Genes BRCA1 / Imunomodulação / Antibióticos Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Linfócitos T / Doxorrubicina / Linfócitos do Interstício Tumoral / Genes BRCA1 / Imunomodulação / Antibióticos Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article