Architecture and assembly of the Type VI secretion system.
Biochim Biophys Acta
; 1843(8): 1664-73, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24681160
ABSTRACT
The Type VI secretion system (T6SS) delivers protein effectors to diverse cell types including prokaryotic and eukaryotic cells, therefore it participates in inter-bacterial competition and pathogenesis. The T6SS is constituted of an envelope-spanning complex anchoring a cytoplasmic tubular edifice. This tubular structure is evolutionarily, functionally and structurally related to the tail of contractile phages. It is composed of an inner tube tipped by a spike complex, and engulfed within a sheath-like structure. This structure assembles onto a platform called "baseplate" that is connected to the membrane sub-complex. The T6SS functions as a nano-crossbow upon contraction of the sheath, the inner tube is propelled towards the target cell, allowing effector delivery. This review focuses on the architecture and biogenesis of this fascinating secretion machine, highlighting recent advances regarding the assembly of the membrane or tail complexes. This article is part of a Special Issue entitled Protein trafficking and secretion in bacteria. Guest Editors Anastassios Economou and Ross Dalbey.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Bactérias
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Proteínas de Bactérias
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Transporte Proteico
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Sistemas de Secreção Bacterianos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article